--- title: Extending value long after the clinical trial with real-world data description: In our series exploring the value of real-world data at each stage of the pharma life cycle, we discuss how RWD enables comprehensive long-term follow up. image: https://blog.healthverity.com/hubfs/Extending%20value%20long%20after%20the%20clinical%20trial%20with%20real-world%20data-blog.png --- Announcing HealthVerity Precision Event Alerts, a next-generation physician alerting solution. 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How We Help - Symphony - Who We Serve - Resources - [Careers](https://healthverity.com/careers/) - [About Us](https://healthverity.com/about-us/) [Request Demo](https://healthverity.com/request-demo/) Featured Content ###### HealthVerity MarketplaceTM The nation’s largest healthcare and consumer data ecosystem ###### taXonomy Pathways Unique features per therapeutic area with claims, labs and EHR including notes ###### HealthVerity eXOs AI-native real-world evidence generation ###### Identity Manager (HVID) Standalone de-identification as a service Data Ecosystem HealthVerity MarketplaceTM HealthVerity TaxonomySM HealthVerity Notes Precision Event Alerts HealthVerity Mastersets Media Measurement Syndicated Audiences Insurance Underwriting Technology Products Identity Manager (HVID) HealthVerity for Clinical Trial Linkage HealthVerity for Commercial Smart Contracts HealthVerity for Registries Symphony Health Platform ###### Symphony Health Overview Seamless Data. 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Symphony Solutions Health technology and business intelligence solutions Integrated Dataverse and Source Solutions Brand strategy and sales HealthRankings Market access Patient Journey Medicines affordability Symphony Products PayerSource® PrescriberSource® PatientSource® PatientSourceCompleteTM PatientSourceDUOTM Symphony FLEXTM CustomerSource® DiagnosticSource® NonRetailSource® Symphony Technology Symphony HealthCloud Synoma Data Integration Vantage Applications Metys ###### Life Sciences Technology solutions from development through commercialization ###### Channel Partners HealthVerity enables partners to unlock unprecedented value and insights for clients ###### Government Comprehensive and compliant solutions to manage the nation’s care ###### Data Ecosystem Partners Join the nation’s largest data partner ecosystem ###### Insurance Insurance-grade solutions that excel in managing risk and rebates ###### HealthVerity Blog Insights and updates from industry experts ###### Publications Peer-reviewed research and discoveries ###### News & Events Stay informed about our latest announcements and happenings ###### The IPGE Approach Fundamentals that power everything that we do and every solution we offer ###### Resource Library Explore guides, webinars, and tools to enhance your understanding ###### Zombie Data Explained Learn how data quality drives better research outcomes [Solutions & Best Practices](https://blog.healthverity.com/tag/solutions-best-practices), [HEOR](https://blog.healthverity.com/tag/heor) # Extending value long after the clinical trial with real-world data [By - HealthVerity,](https://blog.healthverity.com/author/healthverity) May 14, 2024 ![](https://blog.healthverity.com/hubfs/Extending%20value%20long%20after%20the%20clinical%20trial%20with%20real-world%20data-blog.png) In our ongoing series, we have been discussing the value of real-world data (RWD) throughout the pharmaceutical life cycle. We have already reviewed how RWD can [accelerate the path to regulatory approval](https://blog.healthverity.com/accelerating-the-path-to-regulatory-submission-with-rwd) by leveraging it before a clinical trial even starts to inform study design, aid in site selection, discover and recruit ideal patients, and enhance enrollment screening. We also explored its value [during the trial](https://blog.healthverity.com/contextualizing-clinical-trials-with-real-world-data) to limit the impact of patients lost to follow up, conduct concurrent or control arm studies, and monitor healthcare utilization outside of the study. In this installment, we will delve into the benefits RWD can bring long after the trial. #### Superior safety surveillance Synchronizing clinical trial participants with their RWD allows you to conduct long-term follow up, including supporting ongoing safety requirements. Leveraging RWD for safety surveillance can provide insights on long-term outcomes, adverse events, survival, and the overall safety and efficacy of treatments. #### Compare and contrast Comparator studies are increasingly being used due to pressure from payers and regulators. RWD can meet this need by enabling more efficient evaluation of the relative efficacy of a treatment with respect to other drugs on the market, providing the evidence payers require to cover the costs associated with the new treatment. #### Research vulnerable populations Certain populations are often excluded from participating in clinical trials, such as pregnant women. RWD can be used to analyze these subgroups and fill in any evidence gaps. The [HealthVerity Maternal Outcomes Masterset (MOM)](https://healthverity.com/mastersets/mom/) was built for this purpose, providing registry-quality data on over 12 million pregnant women, with more than 3 million newborns synced to their mothers, to support long-term, multi-year pregnancy studies. #### Discover new indications Using RWD, you can also determine the effectiveness of your product in treating additional indications and gain the insights needed to seek regulatory approval. #### Keep the data flowing To keep the insights garnered from RWD flowing after the clinical trial, you need a solution that can capture the clinical trial participants’ personally identifiable information (PII), manage patient identity and govern patient permissions beyond the trial in case of changes in preferences, as well as the ability to retrieve RWD on demand while remaining fully HIPAA compliant. [HealthVerity FLOW](https://healthverity.com/flow/clinical-trials/) provides this end-to-end solution within a 21 CFR Part-11-certified platform.   By implementing HealthVerity FLOW at the beginning of the trial, you can have a single, privacy-protected source of truth for the clinical trial participants’ identity and consent preferences, viewable on an enterprise-wide dashboard, that allows you to seamlessly exchange data from the nation’s largest healthcare and consumer data ecosystem or other third-party sources in a fully HIPAA-compliant manner, powering your long-term follow up studies for the long haul. In our [final installment](https://blog.healthverity.com/enhancing-go-to-market-strategies-with-real-world-data) in this four-part series, we discuss the value real-world data can bring to commercial operations and go-to-market strategies. Read on [here](https://blog.healthverity.com/enhancing-go-to-market-strategies-with-real-world-data). [![Synchronize clinical trial participants with real-world data. 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[READ MORE](https://blog.healthverity.com/extending-value-long-after-the-clinical-trial-with-real-world-data) [![Zombie Data: The silent threat to real-world data in life sciences](https://blog.healthverity.com/hs-fs/hubfs/Zombie-data-3.png?width=352&name=Zombie-data-3.png)](https://blog.healthverity.com/zombie-data-the-silent-threat-to-real-world-data-in-life-sciences) #### [Zombie Data: The silent threat to real-world data in life sciences](https://blog.healthverity.com/zombie-data-the-silent-threat-to-real-world-data-in-life-sciences) By [HealthVerity](https://blog.healthverity.com/author/healthverity) 27 January 2025 In the rapidly evolving world of real-world data (RWD) for life sciences and commercial... [READ MORE](https://blog.healthverity.com/extending-value-long-after-the-clinical-trial-with-real-world-data) #### Who we serve - [Life Sciences](https://healthverity.com/life-sciences/) - [Government](https://healthverity.com/government/) - [Insurance](https://healthverity.com/insurance/) - [Channel Partners](https://healthverity.com/channel-partners/) - [Data Ecosystem Partners](https://healthverity.com/data-ecosystem-partners/) #### How we help - [HealthVerity Marketplace](https://healthverity.com/marketplace/) - [HealthVerity Mastersets](https://healthverity.com/mastersets/) - [HealthVerity FLOW](https://healthverity.com/flow/) - [The IPGE Approach](https://healthverity.com/ipge-approach/) #### Resources - [HealthVerity Blog](https://blog.healthverity.com/) - [News & Events](https://healthverity.com/resources/news-and-events/) - [Resource Library](https://healthverity.com/resources/resource-library/) - [Publications](https://healthverity.com/resources/publications/) #### Our company - [About Us](https://healthverity.com/about-us/) - [Leadership](https://healthverity.com/about-us/#leadership) - [Board of Directors](https://healthverity.com/about-us/#board) - [Careers](https://healthverity.com/careers/) - [Contact](https://healthverity.com/contact/) ©2026 HealthVerity, Inc.    |    [Terms & Conditions](https://healthverity.com/terms-and-conditions/)    |    [Privacy Policy](https://healthverity.com/privacy-policy/) ![](https://px.ads.linkedin.com/collect/?pid=4361946&fmt=gif) ```json { "@context" : "https://schema.org", "@id" : "https://blog.healthverity.com/extending-value-long-after-the-clinical-trial-with-real-world-data#blogposting", "@type" : "BlogPosting", "about" : [ { "@type" : "Thing", "name" : "Real-world data" }, { "@type" : "Thing", "name" : "Clinical trials" }, { "@type" : "Thing", "name" : "Pharmaceutical life cycle" } ], "articleSection" : "Real-World Data", "author" : { "@id" : "https://www.healthverity.com/#organization", "@type" : "Organization", "name" : "HealthVerity", "url" : "https://www.healthverity.com/" }, "dateModified" : "2025-01-22", "datePublished" : "2024-05-14", "description" : "Real-world data can extend the value of clinical trials long after they end by supporting long-term safety surveillance, comparator studies, research in vulnerable populations, discovery of new indications, and ongoing HIPAA-compliant access to insights through identity and consent management.", "headline" : "Extending Value Long After the Clinical Trial With Real-World Data", "inLanguage" : "en", "isPartOf" : { "@id" : "https://blog.healthverity.com/#blog", "@type" : "Blog", "name" : "HealthVerity Blog", "url" : "https://blog.healthverity.com/" }, "keywords" : [ "real-world data", "RWD", "clinical trials", "long-term follow-up", "safety surveillance", "comparator studies", "relative efficacy", "vulnerable populations", "pregnancy studies", "maternal outcomes", "new indications", "regulatory approval", "HIPAA compliance", "patient identity", "patient permissions", "consent management", "HealthVerity FLOW", "21 CFR Part 11" ], "mainEntityOfPage" : { "@id" : "https://blog.healthverity.com/extending-value-long-after-the-clinical-trial-with-real-world-data", "@type" : "WebPage" }, "publisher" : { "@id" : "https://www.healthverity.com/#organization", "@type" : "Organization", "logo" : { "@id" : "https://www.healthverity.com/#logo", "@type" : "ImageObject", "url" : "https://www.healthverity.com/wp-content/uploads/2021/05/HealthVerity-Logo.svg" }, "name" : "HealthVerity", "url" : "https://www.healthverity.com/" } } ``` ```json { "@context" : "https://schema.org", "@id" : "https://blog.healthverity.com/extending-value-long-after-the-clinical-trial-with-real-world-data#faq", "@type" : "FAQPage", "mainEntity" : [ { "@type" : "Question", "acceptedAnswer" : { "@type" : "Answer", "text" : "Real-world data can support long-term follow up by monitoring outcomes and adverse events, enabling comparator studies, filling evidence gaps in populations underrepresented in trials, and helping identify additional indications for a product." }, "name" : "How can real-world data be used after a clinical trial ends?" }, { "@type" : "Question", "acceptedAnswer" : { "@type" : "Answer", "text" : "Synchronizing trial participants with their real-world data enables ongoing safety monitoring and can provide insights into long-term outcomes, adverse events, survival, and the overall safety and efficacy of treatments." }, "name" : "What value does real-world data provide for long-term safety surveillance?" }, { "@type" : "Question", "acceptedAnswer" : { "@type" : "Answer", "text" : "Real-world data can be used to evaluate a treatment’s relative efficacy compared with other therapies on the market, helping generate evidence that payers and regulators may require for coverage and evaluation." }, "name" : "How does real-world data support comparator studies?" }, { "@type" : "Question", "acceptedAnswer" : { "@type" : "Answer", "text" : "Some groups, such as pregnant women, are often excluded from trials. 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