--- title: Contextualizing clinical trials with real-world data description: Explore how real-world data enhances clinical trials by preventing patient loss, enabling concurrent studies, and ensuring compliant data exchange for better outcomes. image: https://blog.healthverity.com/hubfs/Contextualizing-clinical-trials-with-real-world-data-blog.png --- Announcing HealthVerity Precision Event Alerts, a next-generation physician alerting solution. 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How We Help - Symphony - Who We Serve - Resources - [Careers](https://healthverity.com/careers/) - [About Us](https://healthverity.com/about-us/) [Request Demo](https://healthverity.com/request-demo/) Featured Content ###### HealthVerity MarketplaceTM The nation’s largest healthcare and consumer data ecosystem ###### taXonomy Pathways Unique features per therapeutic area with claims, labs and EHR including notes ###### HealthVerity eXOs AI-native real-world evidence generation ###### Identity Manager (HVID) Standalone de-identification as a service Data Ecosystem HealthVerity MarketplaceTM HealthVerity TaxonomySM HealthVerity Notes Precision Event Alerts HealthVerity Mastersets Media Measurement Syndicated Audiences Insurance Underwriting Technology Products Identity Manager (HVID) HealthVerity for Clinical Trial Linkage HealthVerity for Commercial Smart Contracts HealthVerity for Registries Symphony Health Platform ###### Symphony Health Overview Seamless Data. 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Symphony Solutions Health technology and business intelligence solutions Integrated Dataverse and Source Solutions Brand strategy and sales HealthRankings Market access Patient Journey Medicines affordability Symphony Products PayerSource® PrescriberSource® PatientSource® PatientSourceCompleteTM PatientSourceDUOTM Symphony FLEXTM CustomerSource® DiagnosticSource® NonRetailSource® Symphony Technology Symphony HealthCloud Synoma Data Integration Vantage Applications Metys ###### Life Sciences Technology solutions from development through commercialization ###### Channel Partners HealthVerity enables partners to unlock unprecedented value and insights for clients ###### Government Comprehensive and compliant solutions to manage the nation’s care ###### Data Ecosystem Partners Join the nation’s largest data partner ecosystem ###### Insurance Insurance-grade solutions that excel in managing risk and rebates ###### HealthVerity Blog Insights and updates from industry experts ###### Publications Peer-reviewed research and discoveries ###### News & Events Stay informed about our latest announcements and happenings ###### The IPGE Approach Fundamentals that power everything that we do and every solution we offer ###### Resource Library Explore guides, webinars, and tools to enhance your understanding ###### Zombie Data Explained Learn how data quality drives better research outcomes [Solutions & Best Practices](https://blog.healthverity.com/tag/solutions-best-practices) # Contextualizing clinical trials with real-world data [By - HealthVerity,](https://blog.healthverity.com/author/healthverity) April 18, 2024 ![](https://blog.healthverity.com/hubfs/Contextualizing-clinical-trials-with-real-world-data-blog.png) As real-world data (RWD) continues to be increasingly used by the pharmaceutical industry and encouraged by the FDA, we are exploring its value throughout the product life cycle in a four-part blog series. We already discussed how RWD can [accelerate the path to regulatory approval](https://blog.healthverity.com/accelerating-the-path-to-regulatory-submission-with-rwd) before clinical trials even begin. All while informing study design, aiding in site selection, discovering and recruiting ideal patients and aiding enrollment screening. In this installment, we will delve into the benefits of RWD during the clinical trial. #### ![costs-of-a-patient-lost-to-follow-up-1](https://blog.healthverity.com/hs-fs/hubfs/costs-of-a-patient-lost-to-follow-up-1.png?width=300&height=598&name=costs-of-a-patient-lost-to-follow-up-1.png)Prevent "lost to follow-up" patients When a patient stops interacting with trial investigators, or is considered lost to follow up, it can have a serious impact on the clinical trial, leading to increased costs and potential time delays. Perhaps the single most valuable benefit to using RWD during clinical trials is that patients traditionally lost to follow up are never completely lost. If you captured the patient’s consent in advance or through disclosure in the trial IRB, you can continue to follow their healthcare journey through RWD, gaining meaningful insights such as if they have recurring diagnoses, experience potential adverse events, undergo hospitalizations or receive new treatments. #### Seamlessly conduct concurrent studies During a clinical trial, observations may be made that require further investigation or concurrent studies, such as certain populations responding differently, experiencing adverse events or developing comorbid conditions. Additionally, the treatment landscape may evolve, with changes to the standard of care. RWD allows you to rapidly respond to questions that may arise and contextualize the study, providing demographic details for participants, in-depth medical histories and potentially un-reported information that can help researchers better understand treatment responses. #### Administer external control arm studies with ease When circumstances prevent having a portion of trial participants take a placebo, whether because it is a rare disease or due to the severity of the condition, RWD can be used to design and implement a regulatory-grade external control arm. #### Continual monitoring of participant healthcare utilization During a clinical trial, you are reliant on the participant to share with you any health-related events they may experience outside of the trial, such as seeing another doctor, starting a new therapy or being treated in the emergency room. Patient’s don’t always share this information, however, whether because they’re embarrassed, fear they’ll be excused from the study, simply forget or consider it irrelevant. But not having this insight could lead to a critical gap in understanding the safety and efficacy of the drug being studied. RWD offers researchers a reliable means to monitor the healthcare utilization of participants, potentially even further demonstrating the benefits, safety and/or mitigated risks of the drug being studied. #### From patient identity to compliant data exchange, all in one platform To be able to use this valuable RWD throughout the clinical trial and beyond, you need a solution that manages patient identity, governs patient permissions, and enables on-demand retrieval of both de-identified and identifiable data while remaining fully HIPAA compliant. HealthVerity provides this [end-to-end solution](https://healthverity.com/clinical-trial-linkage/) within a 21 CFR Part-11-certified platform.  ![flow-clinical-trial](https://blog.healthverity.com/hs-fs/hubfs/flow-clinical-trial.png?width=4220&height=1700&name=flow-clinical-trial.png) At the beginning of the trial, HealthVerity allows for ingestion of each participant’s personally identifiable information (PII), creating a centralized master that is used to generate HealthVerity IDs (HVIDs) using [HealthVerity Identity Manager](https://healthverity.com/identity-manager/). This creates a privacy-protected, HIPAA-compliant single source of truth with 10x the accuracy of legacy solutions. We also capture patient consent preferences, creating an immutable ledger that lets you know what you can and cannot do with a patient’s data throughout the trial and beyond, tracking changes to preferences and all viewable from an enterprise-class dashboard. This allows for the seamless exchange of both de-identified and identifiable data from the nation’s largest healthcare and consumer [data ecosystem](https://healthverity.com/marketplace/data-ecosystem/), letting the data flow where you need it, when you need it and how you need it in a fully HIPAA-compliant manner so that you can power your analytics of choice. In the next installment of our four-part series, we will discuss the value real-world data can provide long after the clinical trial. [![Synchronize clinical trial participants with real-world data. 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