Heart failure remains one of the most prevalent and costly chronic diseases in the United States, affecting more than 6.7 million adults and projected to reach 8.7 million by 2030.1 It is the leading cause of hospitalization in adults over 65 y/o and contributes to over 400,000 deaths annually, accounting for roughly 45% of cardiovascular mortality.1 In 2020, total direct and indirect heart failure costs reached $46 billion, a figure expected to more than triple by 2050 as prevalence rises.1
Over the past decade, breakthroughs in pharmacologic and device therapy have transformed how heart failure such as congestive heart failure (CHF) is managed. The PARADIGM-HF trial established sacubitril/valsartan (Entresto®) as the first therapy to significantly reduce mortality and hospitalization versus enalapril, setting a new standard of care for patients with reduced ejection fraction (HFrEF).2 Soon after, a newer class of drugs known as SGLT2 inhibitors that were originally developed for diabetes showed strong benefits for patients with heart failure. In large clinical trials, dapagliflozin (Farxiga®) and empagliflozin (Jardiance®) were proven to reduce hospitalizations and improve survival for patients whose hearts have reduced ejection fraction (reduced pumping function), and later for those with preserved ejection fraction (normal pumping function).3,4 These results were exciting and welcome because they expanded heart failure treatment to millions of patients who previously had few effective options.
These advances were then followed by vericiguat (Verquvo®), a soluble guanylate-cyclase stimulator shown in VICTORIA to reduce HF hospitalizations among high-risk patients,5 and by tafamidis (Vyndaqel®)6, which became the first FDA-approved therapy for transthyretin amyloid cardiomyopathy (ATTR-CM), addressing a major underdiagnosed cause of HF in older adults.7 Meanwhile, ongoing trials are exploring next-generation mechanisms such as myosin activators and relaxin agonists to gene and cell-based therapies aimed at reversing myocardial dysfunction rather than simply managing it.8
Recent device innovations are improving CHF care by enabling closer monitoring and smarter intervention through the use of implantable sensors like CardioMEMS and Cordella. Clinicians can monitor pulmonary artery pressure in real time from patient homes, lowering hospitalization risk.9 Institutions are also testing newer tools like left atrial pressure sensors, noninvasive lung-fluid monitors, wearable patches, and neuromodulation or contractility-enhancing devices for patients whose disease remains refractory.
Beyond therapies and hardware, heart failure care is rapidly evolving through remote monitoring, virtual care, and AI prediction tools. For instance, the American Heart Association recently launched a remote support program combining 24/7 virtual monitoring, clinical oversight, and guideline-based care to reduce 30-day readmissions in HF patients by catching decompensation early at home.10 While still in pilot phases, these hybrid models are reshaping the post-hospital care and creating new continuous data streams of symptom reports and alerts.
With this innovation, comes complexity. Researchers and pharmaceutical manufacturers are asking: How well do these therapies perform in routine practice? Which subgroups benefit most? And what are the long-term effects across diverse populations? Answering these questions requires more than just closed claims data (Figure 1).
Claims data remain essential for tracking hospitalizations, procedures, and medication use, but they miss the clinical nuance that defines heart failure management. For example:
Without these data, researchers can’t accurately measure treatment response, adherence, or safety. For example, a claim may show that a patient filled sacubitril/valsartan once, but lab data might reveal rising creatinine that led to discontinuation, or notes might document symptomatic improvement that claims don't capture (Figure 2)
Figure 2: Example of a CHF pathway
The opportunity for manufacturers, researchers, and healthcare stakeholders is to bridge this data gap and gain a comprehensive view of the heart failure treatment journey. By integrating closed payer claims with laboratory results and EHR, including physician notes, researchers can uncover insights that were previously hidden. This is particularly valuable for teams in health economics and outcomes research (HEOR), epidemiology, and pharmacovigilance who are tasked with evaluating real-world performance and long-term outcomes of heart failure therapies.
With the right data:
These insights simply aren’t possible with claims alone. They require longitudinal datasets that combine utilization, clinical measures, and narrative context to show how therapies perform in everyday care (Figure 2).
taXonomy Pathways brings together closed payer claims, laboratory data, and EHR, including physician notes, to reveal the complete heart failure journey with a focus on CHF the most clinically complex and costly form of the disease.
The CHF dataset is anchored by the nation’s largest closed claims universe, spanning hundreds of payers and covering more than 6.4 million de-identified CHF patients across nine years of adjudicated medical and pharmacy history. Over 5.8 million also have pharmacy claims. This foundation is enriched with laboratory data from the two largest U.S. outpatient networks, representing over 60% of all cardiac biomarker testing, and EHR data including millions of clinical notes that capture disease severity, hospital course, and recovery patterns.
What makes taXonomy Pathways unique is the depth of biomarker coverage across its heart failure datasets. It captures cardiac and renal measures such as NT-proBNP, BNP, troponin, eGFR, and sodium for millions of patients. These data points that are often unavailable from competing real-world data sources. This clinical granularity enables direct assessment of disease severity, treatment response, and safety signals in ways that claims-only datasets simply cannot support.
Within this combined dataset, researchers can analyze:
By connecting claims with detailed clinical data, taXonomy Pathways enables researchers and manufacturers to quantify outcomes that claims alone cannot show—such as how early biomarker improvement predicts reduced rehospitalization, or how renal trends inform treatment adjustments. This integrated, research-ready CHF dataset allows HEOR, RWE, and epidemiology teams to evaluate real-world treatment effectiveness, safety, and progression in one place, without the complexity of stitching together fragmented data sources.
Watch our webinar where we dive deeper into CHF real-world evidence. In the meantime, if you are exploring heart failure or other cardiovascular disease outcomes, we can help design a tailored real-world study. Tell us your population of interest and endpoints. With taXonomy Pathways, we will deliver a dataset and analysis framework that you simply cannot see in claims data alone.