HealthVerity Blog

Accelerating real-world evidence with agentic AI

Written by HealthVerity | Nov 13, 2025 10:00:00 AM

Real-world evidence (RWE) studies often stall on the same friction points: defining the most appropriate cohort, identifying the relevant codes, and curating data to produce an analysis ready dataset. Often external partners and datasets don't offer transparency resulting in a lack of insights and the ability to reproduce findings.

For emerging and mid-size biopharma, especially teams without resources, including budget or a large bench of analysts, those steps can stretch from weeks to months and even years if they involve manual collection of patient data. To meet the market demands, HealthVerity eXOS applies an agentic AI approach to compress that research cycle.1 In practice this means autonomous but human-researcher supervised agents translate a plain-English question about real-world data into structured designs, execute data prep and analyses, and return interpretable outputs with human checkpoints.1 

The most noticeable gains tend to be turnaround time on standard epidemiologic questions, generation of meaningful figures and graphics and a clear methodology including the full code used, that can be reviewed by other researchers. That combination is particularly powerful for smaller organizations that need credible RWE quickly without a heavy data analysis infrastructure.

 

Prompt example given to HealthVerity eXOs. 

Agentic AI supports RWE and epidemiological studies

Think of HealthVerity eXOs as an evidence studio rather than a black box of AI. The platform carries out familiar epidemiologic designs that cover much of day-to-day RWE questions with applied enrollment periods. Some common examples (but not limited to) include:

  • Feasibility and market assessment: Inclusion/exclusion logic, index dates, baseline characteristics, attrition and more.

  • Epidemiology (incidence, prevalence): Consistent denominators, look-back windows, washout rules for rate calculations, etc.

  • Treatment patterns such as adherence and persistence: Common measures (PDC/MPR), gap thresholds, on-treatment windows and switch/discontinuation detection and more.

  • Time-to-event or procedure: Survival analyses for initiation, discontinuation, or therapy change with transparent censoring rules, etc.

  • Comparative outcomes (where appropriate): Configurable endpoints (e.g., mortality, hospitalization) with pre-specified model families and effect-estimate reporting.

By capturing definitions, parameters, and execution details, it makes the mechanical parts of RWE easier to repeat across therapeutic areas and study variants because the output and  “step-by-step thought process” of the tool is fully visible to the user, and can be edited even before analysis begins. 

Accelerate smarter clinical trial design

Beyond retrospective epidemiology, HealthVerity eXOs can also accelerate stages of clinical development by bringing real-world evidence into trial design, feasibility, and post-market evaluation

In early planning, agentic AI can use HealthVerity real-world healthcare data (RWD) to identify and characterize potential patient populations and estimate enrollment feasibility across therapeutic areas or geographies. During protocol design, the same workflow can uncover baseline event rates, treatment pathways, and comorbidity patterns. Once a study is underway, HealthVerity eXOs can analyze control arm comparators using real-world populations. After approval, the same framework scales into safety signal monitoring, label expansion analyses, and outcomes analysis, creating continuity between pre-market research and post-market evidence generation.

So where is AI obtaining all this real-world data? 

HealthVerity eXOs runs directly on HealthVerity RWD. That means your studies execute against fully privacy-compliant healthcare data that is routinely updated from sources with clear data rights and usage controls. For researchers, the practical upside is less time wrestling with data onboarding and more time specifying the question and reviewing results.

Agentic workflow in HealthVerity eXOS

HealthVerity eXOS accelerates real-world evidence generation by turning traditional, linear study workflows into an automated, agentic pipeline. What once required long manual coordination across data, analytics and documentation now runs in a structured sequence of supervised AI-driven steps. The method is simple to describe and powerful in practice: 

Ask → Design → Prepare → Analyze → Interpret

  • In Ask, the researcher prompts the intent, population, exposure, outcomes, time horizon, and assumptions.

  • Design turns that intent into structured cohort definitions and an analysis plan with parameter grids.

  • Prepare assembles the dataset using versioned definitions and runs basic readiness checks for missingness, plausibility, and timing.

  • Analyze executes the chosen estimators and diagnostics deterministically, using fixed seeds and locked environments.

  • Interpret summarizes results alongside the exact definitions and parameters used, ready for human review and sign-off.

Answer more questions faster with HealthVerity eXOs

For emerging and mid-size biopharma teams, HealthVerity eXOS offers a practical way to speed up credible RWE by standardizing core methods and making each step reproducible and reviewable. You get consistent study designs, transparent lineage, and faster turnaround without a dedicated analytics organization. A recent webinar wrap-up covered the capabilities of HealthVerity eXOs in detail, read more here.

If you’d like to pressure-test your current business questions, consider sharing up to 3 questions and we'll run them through HealthVerity eXOs and share the method and results. Ready to see how your questions perform under an agentic workflow? Let’s set up a demo.

References

  1. HealthVerity Inc. Announcing HealthVerity eXOS: Accelerated real-world evidence for emerging biopharma, powered by Medeloop, through groundbreaking agentic AI. Press release. Philadelphia (PA) & San Francisco (CA); September 30, 2025. Available at: https://healthverity.com/news/announcing-healthverity-exos/