--- title: The role of real-world data in advancement of Alzheimer’s treatments description: Discover how integrated real-world data helps researchers improve Alzheimer’s clinical trials, study disease progression and generate real-world evidence. image: https://blog.healthverity.com/hubfs/aiding-the-advancement-of-alzheimers-treatment-blog.png --- Announcing HealthVerity Precision Event Alerts, a next-generation physician alerting solution. [Learn more](https://healthverity.com/news/healthverity-precision-event-alerts-launch/) - [Contact](https://healthverity.com/contact/) - [Sign In](https://marketplace.healthverity.com/login/?next=/marketplace/) [![HealthVerity-Logo-Dark-3](https://blog.healthverity.com/hs-fs/hubfs/HealthVerity-Logo-Dark-3.png?width=1662&height=320&name=HealthVerity-Logo-Dark-3.png)](https://healthverity.com/) - How We Help - Featured Content - [HealthVerity MarketplaceTM](https://healthverity.com/marketplace/healthverity-marketplace/) - [HealthVerity TaxonomySM](https://healthverity.com/taxonomy-portal/) - [Life Sciences](https://healthverity.com/life-sciences/) - [Identity Manager (HVID)](https://healthverity.com/identity-manager/) - Data Ecosystem - [HealthVerity MarketplaceTM](https://healthverity.com/marketplace/healthverity-marketplace/) - [HealthVerity TaxonomySM](https://healthverity.com/taxonomy-portal/) - [Precision Event Alerts](https://healthverity.com/precision-event-alerts/) - [HealthVerity Mastersets](https://healthverity.com/mastersets/portal/) - [Media Measurement](https://healthverity.com/media-measurement/) - [Insurance Underwriting](https://healthverity.com/insurance-underwriting/) - Technology Products - [Identity Manager (HVID)](https://healthverity.com/identity-manager/) - [HealthVerity FLOW](https://healthverity.com/flow/portal/) - [Governance Manager](https://healthverity.com/governance-manager/) - [Smart Contracts](https://healthverity.com/smart-contracts-manager/) - Symphony - Symphony Health Platform - [Symphony Health Overview](https://healthverity.com/symphony-health/overview/) - [Integrated Dataverse](https://healthverity.com/symphony-health/integrated-dataverse-and-source-solutions/) - [Symphony HealthCloud](https://healthverity.com/symphony-health/health-technology-and-business-intelligence-solutions/) - Symphony Solutions - [Health technology and business intelligence solutions](https://healthverity.com/symphony-health/health-technology-and-business-intelligence-solutions/) - [Integrated Dataverse and Source Solutions](https://healthverity.com/symphony-health/integrated-dataverse-and-source-solutions/) - [Brand strategy and sales](https://healthverity.com/symphony-health/optimize-brand-strategy-and-sales-effectiveness/) - [HealthRankings](https://healthverity.com/symphony-health/health-rankings/) - [Market access](https://healthverity.com/symphony-health/solve-market-access-challenges/) - [Patient Journey](https://healthverity.com/symphony-health/understand-the-patient-journey/) - [Medicines affordability](https://healthverity.com/symphony-health/making-medicines-more-affordable/) - Symphony Products - [PayerSource®](https://blog.healthverity.com/hubfs/HealthVerity-Symphony-PDFs/HealthVerity-Symphony-Health-Factsheet-PayerSource.pdf) - [PrescriberSource®](https://blog.healthverity.com/hubfs/HealthVerity-Symphony-PDFs/HealthVerity-Symphony-Health-Factsheet-PrescriberSource.pdf) - [PatientSource®](https://blog.healthverity.com/hubfs/HealthVerity-Symphony-PDFs/HealthVerity-Symphony-Health-Factsheet-PatientSource.pdf) - [PatientSourceCompleteTM](https://blog.healthverity.com/hubfs/HealthVerity-Symphony-PDFs/HealthVerity-Symphony-Health-Factsheet-PatientSourceComplete.pdf) - [PatientSourceDUOTM](https://blog.healthverity.com/hubfs/HealthVerity-Symphony-PDFs/HealthVerity-Symphony-Health-Factsheet-PatientSourceDUO.pdf) - [Symphony FLEXTM](https://blog.healthverity.com/hubfs/HealthVerity-Symphony-PDFs/HealthVerity-Symphony-Health-Factsheet-Symphony-FLEX.pdf) - [CustomerSource®](https://healthverity.com/symphony-health/integrated-dataverse-and-source-solutions/) - [DiagnosticSource®](https://blog.healthverity.com/hubfs/HealthVerity-Symphony-PDFs/HealthVerity-Symphony-Health-Factsheet-DiagnosticSource.pdf) - [NonRetailSource®](https://blog.healthverity.com/hubfs/HealthVerity-Symphony-PDFs/HealthVerity-Symphony-Health-Factsheet-NonRetailSource.pdf) - Symphony Technology - [Symphony HealthCloud](https://healthverity.com/symphony-health/health-technology-and-business-intelligence-solutions/) - [Synoma Data Integration](https://healthverity.com/symphony-health/health-technology-and-business-intelligence-solutions/) - [Vantage Applications](https://blog.healthverity.com/hubfs/HealthVerity-Symphony-PDFs/HealthVerity-Symphony-Health-Factsheet-Vantage-Applications.pdf) - [Metys](https://healthverity.com/symphony-health/health-technology-and-business-intelligence-solutions/metys/) - Who We Serve - [Life Sciences](https://healthverity.com/life-sciences/) - [Government](https://healthverity.com/government/) - [Insurance](https://healthverity.com/insurance/) - [Channel Partners](https://healthverity.com/channel-partners/) - [Data Ecosystem Partners](https://healthverity.com/data-ecosystem-partners/) - Resources - [HealthVerity Blog](https://blog.healthverity.com/) - [News & Events](https://healthverity.com/resources/news-and-events/) - [Resource Library](https://healthverity.com/resources/resource-library/) - [Publications](https://healthverity.com/resources/publications/) - [The IPGE Approach](https://healthverity.com/ipge-approach/) - [Zombie Data Explained](https://healthverity.com/get-verified/) - [Careers](https://healthverity.com/careers/) - [About Us](https://healthverity.com/about-us/) [Request Demo](https://healthverity.com/request-demo/) [Contact](https://healthverity.com/contact/) [Sign In](https://marketplace.healthverity.com/) [![Logo](https://blog.healthverity.com/hubfs/social-suggested-images/healthverity.comwp-contentuploadshealthverity-2023-logo2x.png)](https://healthverity.com/) - How We Help - Symphony - Who We Serve - Resources - [Careers](https://healthverity.com/careers/) - [About Us](https://healthverity.com/about-us/) [Request Demo](https://healthverity.com/request-demo/) Featured Content ###### HealthVerity MarketplaceTM The nation’s largest healthcare and consumer data ecosystem ###### taXonomy Pathways Unique features per therapeutic area with claims, labs and EHR including notes ###### HealthVerity eXOs AI-native real-world evidence generation ###### Identity Manager (HVID) Standalone de-identification as a service Data Ecosystem HealthVerity MarketplaceTM HealthVerity TaxonomySM HealthVerity Notes Precision Event Alerts HealthVerity Mastersets Media Measurement Syndicated Audiences Insurance Underwriting Technology Products Identity Manager (HVID) HealthVerity for Clinical Trial Linkage HealthVerity for Commercial Smart Contracts HealthVerity for Registries Symphony Health Platform ###### Symphony Health Overview Seamless Data. Stronger Insights. Smarter Decisions. ###### Integrated Dataverse Integrated Dataverse (IDV®) is de-identified claims data platform that combines medical, hospital, prescription, and demographic data into a single unifed view. ###### Symphony HealthCloud Securely store, integrate, access, and analyze virtually unlimited volumes of data with Symphony HealthCloud. Symphony Solutions Health technology and business intelligence solutions Integrated Dataverse and Source Solutions Brand strategy and sales HealthRankings Market access Patient Journey Medicines affordability Symphony Products PayerSource® PrescriberSource® PatientSource® PatientSourceCompleteTM PatientSourceDUOTM Symphony FLEXTM CustomerSource® DiagnosticSource® NonRetailSource® Symphony Technology Symphony HealthCloud Synoma Data Integration Vantage Applications Metys ###### Life Sciences Technology solutions from development through commercialization ###### Channel Partners HealthVerity enables partners to unlock unprecedented value and insights for clients ###### Government Comprehensive and compliant solutions to manage the nation’s care ###### Data Ecosystem Partners Join the nation’s largest data partner ecosystem ###### Insurance Insurance-grade solutions that excel in managing risk and rebates ###### HealthVerity Blog Insights and updates from industry experts ###### Publications Peer-reviewed research and discoveries ###### News & Events Stay informed about our latest announcements and happenings ###### The IPGE Approach Fundamentals that power everything that we do and every solution we offer ###### Resource Library Explore guides, webinars, and tools to enhance your understanding ###### Zombie Data Explained Learn how data quality drives better research outcomes [Solutions & Best Practices](https://blog.healthverity.com/tag/solutions-best-practices), [HEOR](https://blog.healthverity.com/tag/heor), [taXonomy Pathways](https://blog.healthverity.com/tag/taxonomy-pathways) # The role of real-world data in advancement of Alzheimer’s treatments [By - HealthVerity,](https://blog.healthverity.com/author/healthverity) April 3, 2026 ![](https://blog.healthverity.com/hubfs/aiding-the-advancement-of-alzheimers-treatment-blog.png) One in nine Americans age 65 and older has Alzheimer’s disease (AD), a devastating illness that gradually erodes memory and cognitive function, affecting patients and their families long before the disease reaches its final stages.¹ As the population ages, the burden will continue to grow. By 2030, 20% of the U.S. population is expected to be age 65 or older, increasing the number of people at risk for developing Alzheimer’s disease.¹ There is still no cure for this progressive and fatal form of dementia. While seven therapies have received approval from the Food and Drug Administration (FDA) and more than 180 clinical trials are evaluating potential treatments, developing effective therapies remains a complex challenge.¹ ² Advancing Alzheimer’s research requires a deeper understanding of how the disease is diagnosed, monitored and treated across real-world care settings. [taXonomy Pathways](https://healthverity.com/pathways/) brings together claims, lab results and electronic health records (EHR) into research-ready datasets that allow investigators to study the Alzheimer’s patient journey and generate evidence to support new treatment development. ![taxonomy-pathways-diagram-alt](https://blog.healthverity.com/hs-fs/hubfs/taxonomy-pathways-diagram-alt.png?width=811&height=359&name=taxonomy-pathways-diagram-alt.png) ## Why Alzheimer’s clinical trial sites often miss the patients who need them most The Alzheimer’s Association reported that clinical trial sites for memory impairment drugs do not cohesively align with areas that have larger populations of individuals 60 years of age and older, causing strain on sites in areas of higher density senior populations and leaving other individuals having to travel 50 miles to get to a clinical trial site. This has led to lower performance and delayed timelines.3 Additionally, Alzheimer’s disease disproportionately affects minorities, with 19% of Black/African American and 14% of Hispanic/Latino adults age 65 and older having AD, compared to 10% of White/Caucasian seniors.1 HealthVerity RWD allows researchers to analyze the demographic composition of patient populations across the healthcare system. By combining medical claims, pharmacy data and social determinants of health signals, investigators can identify providers who treat patient populations most affected by Alzheimer’s disease. This approach helps research teams select clinical trial sites that better reflect real-world disease burden, improving recruitment and supporting more representative study populations.   ### Using real-world data to demonstrate safety and effectiveness of Alzheimer’s therapies In order for new Alzheimer's drugs to be accepted by doctors, payers, regulators and, most importantly, patients, pharmaceutical companies need to create a robust body of evidence that demonstrates product safety and effectiveness in the real world. This presents unique challenges, because traditional sources of real-world data (RWD), such as claims or electronic health records (EHRs) alone, do not capture key measures of AD progression. With the nation’s largest healthcare and consumer data ecosystem, representing over 4 million diagnosed AD patients, HealthVerity offers the most novel and diverse data sources, including: - **Infusion center data** to capture how the latest AD products are being prescribed in the real world - **Long-term care EMR data** to analyze cognitive test scores over time - **Genetic lab testing data** to understand the presence of the APOE-e4 gene, commonly associated with AD - **Open and closed payer claims** to reveal the AD patient’s longitudinal healthcare journey with the most extensive commercial, Medicaid and Medicare coverage - **Outpatient lab results** representing 65% of the outpatient market for the detection of beta-amyloid proteins in spinal taps ![taXonomy Pathways provides comprehensive data points on Alzheimer's disease throughout a patient's journey through the healthcare system.](https://blog.healthverity.com/hs-fs/hubfs/AD%20data%20alzheimers-1.png?width=736&height=472&name=AD%20data%20alzheimers-1.png) All of this data is fully interoperable, privacy-protected and delivered directly to your environment of choice in a normalized common data model for you to apply fit-for-purpose analytics, available through [taXonomy Pathways](https://healthverity.com/pathways/).    ### Advancing Alzheimer’s research with integrated real-world data Nearly 14 million people in the U.S. are expected to live with Alzheimer’s disease by 2060.1 Advancing research requires more than claims data alone. With taXonomy Pathways, HealthVerity brings together closed claims, lab results and electronic health records into research-ready datasets that allow investigators to study diagnosis, testing patterns and treatment use across the Alzheimer’s patient journey.  Through the HealthVerity IPGE approach, we bring together identity resolution, privacy protections and governance controls that support accurate patient matching across disparate datasets while respecting data rights and usage permissions. Frameworks such as[taXonomy Pathways](https://healthverity.com/pathways/) build on this foundation, organizing integrated claims, lab and electronic health record data into research-ready patient journeys. [![Close the evidence gap with taXonomy Pathways](https://no-cache.hubspot.com/cta/default/5412465/interactive-196135223637.png)](https://blog.healthverity.com/hs/cta/wi/redirect?encryptedPayload=AVxigLJrgsisLGqg5WcHZeyq6UpGCkR97uxeCyC8T2pri8kzpXsVYpxlhu4WevXyPFwOf9H7nJGnRPzXgLJO7KvKRAqxaFEOlN640ripJOUsb%2BZmt5BvV6HRrX8g0E6U%2FINuYD6d2mxdMOl73zmyvnZtwctf%2F2lCMdXvQhVuvC9biMUfuBtoYUA%3D&webInteractiveContentId=196135223637&portalId=5412465) ## References 1. Alzheimer’s Association. 2023 Alzheimer’s Disease Facts and Figures. [https://www.alz.org/media/Documents/alzheimers-facts-and-figures.pdf](https://www.alz.org/media/Documents/alzheimers-facts-and-figures.pdf) 2. Cummings, J.; Zhou, Y.; Lee, G.; et al (2023). Alzheimer’s disease drug development pipeline: 2023. Alzheimer’s & Dementia. Volume 9, Issue 2. April-June 2023. 3. Stanton, S.; Dwyer, J.; Ward, N.; Vradenburg, G.; Taylor, J. (2020). Are U.S. clinical trial sites in the right places to meet the demand for the population density of those over 60? Alzheimer’s & Dementia, vol. 16, issue 10, December 7, 2020. [https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.044244](https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.044244)  ###### [![Explore closed claims & labs & EHR with one solution](https://no-cache.hubspot.com/cta/default/5412465/interactive-209041299597.png)](https://blog.healthverity.com/hs/cta/wi/redirect?encryptedPayload=AVxigLKtO3bxYd%2Bx03o1yL2a3M4NkBS%2FFV6gBs%2Biuh1AMOHF2PFpU18pTaBFZ8MWp5S9LddGjHvSWbKbP%2Fiv68GLX1UqF51Sw2Sbja1Omnsl0nbDc55MGt2%2F%2B6N%2F%2F5VnGtyeLuBgnFqMpIYn9gtxv0LeEAg%2BA%2Fv%2BiIvGGaVZHd19cCHPacavEIk%3D&webInteractiveContentId=209041299597&portalId=5412465) ###### Category - [Solutions & Best Practices](https://blog.healthverity.com/tag/solutions-best-practices) - [Trends & Insights](https://blog.healthverity.com/tag/trends-insights) - [HEOR](https://blog.healthverity.com/tag/heor) - [Thought Leadership](https://blog.healthverity.com/tag/thought-leadership) - [Marketplace](https://blog.healthverity.com/tag/marketplace) - [taXonomy](https://blog.healthverity.com/tag/taxonomy) - [Industry Updates](https://blog.healthverity.com/tag/industry-updates) - [Case Studies](https://blog.healthverity.com/tag/case-studies) - [Government](https://blog.healthverity.com/tag/government) - [Commercial Pharmaceutical](https://blog.healthverity.com/tag/commercial-pharmaceutical) - [AI](https://blog.healthverity.com/tag/ai) - [eXOs](https://blog.healthverity.com/tag/exos) - [Audiences](https://blog.healthverity.com/tag/audiences) - [taXonomy Pathways](https://blog.healthverity.com/tag/taxonomy-pathways) - [Notes](https://blog.healthverity.com/tag/notes) - [Rare Diseases](https://blog.healthverity.com/tag/rare-diseases) ###### Popular Post - [The GLP-1 trend: What the real-world data reveals](https://blog.healthverity.com/the-glp-1-surge-what-the-real-world-data-reveals) - [GLP-1 trends 2025: real-world data, patient outcomes & future therapies](https://blog.healthverity.com/glp-1-trends-2025-real-world-data-patient-outcomes-future-therapies) - [Open claims vs. closed payer claims: What’s the difference?](https://blog.healthverity.com/open-claims-vs-closed-payer-claims) - [What is Privacy Preserving Record Linkage (PPRL)?](https://blog.healthverity.com/what-is-privacy-preserving-record-linkage) - [GLP‑1 real‑world data for obesity: A new standard for metabolic care](https://blog.healthverity.com/glp-1-real-world-data-for-obesity-a-new-standard-for-metabolic-care) ###### Subscribe ### Similar Blogs [![Alzheimer’s disease in the real world: Where evidence matters most](https://blog.healthverity.com/hs-fs/hubfs/alzheimers.webp?width=352&name=alzheimers.webp)](https://blog.healthverity.com/alzheimers-disease-in-the-real-world-where-evidence-matters-most) #### [Alzheimer’s disease in the real world: Where evidence matters most](https://blog.healthverity.com/alzheimers-disease-in-the-real-world-where-evidence-matters-most) By [HealthVerity](https://blog.healthverity.com/author/healthverity) 10 November 2025 Alzheimer’s disease burden and the current therapy pipeline Alzheimer’s disease remains the leading... [READ MORE](https://blog.healthverity.com/the-role-of-real-world-data-in-advancement-of-alzheimers-treatments) [![Menopause at a turning point: RWD matters more than ever](https://blog.healthverity.com/hs-fs/hubfs/menopause-at-a-turning-point.png?width=352&name=menopause-at-a-turning-point.png)](https://blog.healthverity.com/menopause-at-a-turning-point-rwd-matters-more-than-ever) #### [Menopause at a turning point: RWD matters more than ever](https://blog.healthverity.com/menopause-at-a-turning-point-rwd-matters-more-than-ever) By [HealthVerity](https://blog.healthverity.com/author/healthverity) 13 July 2026 A recent CNBC article used HealthVerity real-world data (RWD) to highlight a shortage of estrogen... [READ MORE](https://blog.healthverity.com/the-role-of-real-world-data-in-advancement-of-alzheimers-treatments) [![The Missing Pieces: How Rare Disease Diagnoses Come Together](https://blog.healthverity.com/hs-fs/hubfs/the-missing-pieces-how-rare-disease-diagnoses-come-together-featured.png?width=352&name=the-missing-pieces-how-rare-disease-diagnoses-come-together-featured.png)](https://blog.healthverity.com/the-missing-pieces-how-rare-disease-diagnoses-come-together) #### [The Missing Pieces: How Rare Disease Diagnoses Come Together](https://blog.healthverity.com/the-missing-pieces-how-rare-disease-diagnoses-come-together) By [HealthVerity](https://blog.healthverity.com/author/healthverity) 26 February 2026 Rare diseases may be individually uncommon, but collectively they affect an estimated 30 million... [READ MORE](https://blog.healthverity.com/the-role-of-real-world-data-in-advancement-of-alzheimers-treatments) #### Who we serve - [Life Sciences](https://healthverity.com/life-sciences/) - [Government](https://healthverity.com/government/) - [Insurance](https://healthverity.com/insurance/) - [Channel Partners](https://healthverity.com/channel-partners/) - [Data Ecosystem Partners](https://healthverity.com/data-ecosystem-partners/) #### How we help - [HealthVerity Marketplace](https://healthverity.com/marketplace/) - [HealthVerity Mastersets](https://healthverity.com/mastersets/) - [HealthVerity FLOW](https://healthverity.com/flow/) - [The IPGE Approach](https://healthverity.com/ipge-approach/) #### Resources - [HealthVerity Blog](https://blog.healthverity.com/) - [News & Events](https://healthverity.com/resources/news-and-events/) - [Resource Library](https://healthverity.com/resources/resource-library/) - [Publications](https://healthverity.com/resources/publications/) #### Our company - [About Us](https://healthverity.com/about-us/) - [Leadership](https://healthverity.com/about-us/#leadership) - [Board of Directors](https://healthverity.com/about-us/#board) - [Careers](https://healthverity.com/careers/) - [Contact](https://healthverity.com/contact/) ©2026 HealthVerity, Inc.    |    [Terms & Conditions](https://healthverity.com/terms-and-conditions/)    |    [Privacy Policy](https://healthverity.com/privacy-policy/) ![](https://px.ads.linkedin.com/collect/?pid=4361946&fmt=gif)